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17th International Conference on Nephrology & Urology

London, UK

Suresh Mathew

Suresh Mathew

Christian Hospital, USA

Title: Vascular calcification: An imminent disease epidemic


Biography: Suresh Mathew


Vascular calcification reduces vessel elasticity. The consequence of this leads to cardiovascular morbidity and mortality.
The extent of calcium deposits in vessel walls are key risk factors for ischemic events. The best studied is coronary artery
calcification because of CT based imaging modalities. Coronary artery calcification is markedly increased in patients with
chronic kidney disease. Research has shown vascular calcification is an active and complex process that involves numerous
mechanisms responsible for calcium deposition in arterial walls. Indeed, the majority of vascular calcification is thought to
be de-differentiation of vascular smooth muscle cells to osteoblast/chondrocyte like cells. The pathology, molecular biology,
potential mechanism and the latest therapeutic options will be discussed.