Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 17th International Conference on Nephrology & Urology London , UK.

Day 2 :

OMICS International Nephrology Urology 2018 International Conference Keynote Speaker Riitta Lassila photo
Biography:

Riitta Lassila has completed her MD in 1983 from Helsinki University, PhD in 1989, and postdoctoral studies at Mount Sinai University School of Medicine in N.Y. She is an internist and the Head of Coagulation Disorders Unit in Helsinki University Hospital since 2000 and Professor of Coagulation Medicine in Helsinki University since 2013. She has published more than 220 papers in peer-reviewed journals and has served as editor in Thrombosis Research and editorial board member of Haemophilia. She is the secretary of European Association of Haemophilia and Allied Disorders and steering committee member of EUHANET and EUHASS.       She is CSO in Aplagon Oy developing APACs as pharamceutical entities.

Abstract:

 APACs are unique dual antiplatelet and anticoagulant molecules, which mimic the vascular tissue residing mast cell heparin proteoglycans. Platelet activation and interaction with vascular wall with ensuing coagulation are important pathogenic mechanisms underlying various diseases, including kidney disease. We have shown that in ANCA-vasculitis kidney function is associated with strong coagulation activity during the acute phase, and that vascular access problems are prevalent in dialysis patients with coagulation abnormalities or thrombophilias. We have studied our potent, naturally occurring, locally acting antithrombotic in prevention of ischemic short- and long-term reversible or irreversible kidney injuries.

APACs show strong inhibition of collagen-induced platelet aggregation and procoagulant activity in association with vascular damage. In various animal models we have shown that APAC is able to target vascular injury site from the circulation and upon local application, having a long vascular retention time. Being  highly negatively charged large molecules (MW 200-400 kDa) APACs interact avidly with vascular von Willebrand factor, laminin and collagen, whereas PECAM and podocalyxin positive vascular sites fail to colocalize with APAC. When infused intravenously 10 min prior to arterial clamping APAC protected kidneys from ischemic reperfusion injury, assessed both by clinical and laboratory or pathology findings. Intriguingly, in severe irreversible injury of 60 min ischemia time, APAC provided renoprotection. We are currently working with a diabetic nephropathy mouse model to study the possible role of APAC in the development of streptozotocin-induced diabetes and kidney damage. 

Keynote Forum

Afshar Zomorrodi

Imam Reza Hospital-Tabriz University of Medical Sciences, Iran

Keynote: Does early removal of foley cather have any influence on infection of recipient post renal transplantation? Is it safe? A clinical trial study

Time : 10:40-11:20

OMICS International Nephrology Urology 2018 International Conference Keynote Speaker Afshar Zomorrodi photo
Biography:

Afshar Zomorrodi is a Professor of Urology and Kidney Transplant Surgeon, Chief of Organ Transplant Department of Imam Reza Hospital, Tabriz Medical Science
University, Tabriz-Iran. He completed his education in Tehran University (1974-1981), Tehran, Iran, and MD degree during 1986-1990. He gained a Fellowship in Kidney
Transplantation during 1992-1994 from Tabriz Medical Science University, Tabriz, Iran. He gained an Observership in Kidney Transplant and Pediatric Urology, Sickkid’s
Hospital, Toronto, Canada in 2001.

Abstract:

Introduction: Kidney transplant is a fair option for treatment of a chronic renal failure, although the outcome and results of
kidney transplant are good, but it may be associated with some complications. One of the important complications is urinary
infection. The aim of this study was to investigate the role of early removing of the catheter in renal transplant patients on the
reduction of urinary tract infections.
Materials & Methods: This study was conducted as a clinical trial. 88 transplanted patients were enrolled and randomly divided
into two groups. In the first group, the catheter of patients was taken 3 days after the transplant, and in the second group, the
catheter of patients were removed 7 days after the transplantation. Urine culture was performed on two occasions. Then, the
patient data entered the SPSS v20 statistical analysis program and analyzed the data.
Results: In this study, 25 patients (56.8%) were male in the first group and the mean age of the patients was 43.52±13.6 years.
In the second group, 25 patients (56.8%) were female and the mean age of the patients was 43.20±14.39 years. After examining
patients' urine tests and analyzing data with T test, the incidence of infection on the day after catheter exits (P=0.000) and 7 days
after the expulsion of the catheter (P=0.009) in the patients in the first group (three days). It was significantly less than the second
group.
Conclusion: Early removal of catheter has fundamental effects on UTI post kidney transplant and it seems that early removal of
urethral catheter may be safe and reasonable in renal transplant of the recipient patient.